Dppa3 facilitates self-renewal of embryonic stem cells by stabilization of pluripotent factors
Abstract Background Developmental pluripotency-associated 3 (Dppa3, also called Stella or PGC7) is a principal maternal protein specially expressed in pre-implantation embryos, embryonic stem cells (ES cells) and primordial germ cells (PGCs).It plays critical role in the nuage sofa regulating of DNA methylation in zygotes and oocytes.However, the e